"Providing genetic analysis services since 1995"

Staff

     Dr Andrew Cassidy

Andrew James Cassidy completed his first Degree at the University of Abertay, later moving to the University of Dundee to complete an MSc in Molecular Biology followed by a PhD in Molecular Genetics. While carrying out this research work he initiated and developed the University's first DNA Sequencing Facility. Now Head of Genetics Core Services he continues to develop and expand the range of services on offer to the clinical and academic communities both in and beyond Dundee.         

Publications

  1. Clarke DJ, Cassidy AJ, See CG et al. Cloning of the human UGT1 gene complex in yeast artificial chromosomes: novel aspects of gene structure and subchromosomal mapping to 2q37. Biochem Soc Trans 1997; 25: S562.
  2. Clarke DJ, Moghrabi N, Monaghan G et al. Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias. Clin Chim Acta 1997; 266: 63-74.
  3. Jedlitschky G, Cassidy AJ, Sales M et al. Cloning and characterization of a novel human olfactory UDP- glucuronosyltransferase. Biochem J 1999; 340: 837-43.
  4. Monaghan G, McLellan A, McGeehan A et al. Gilbert's syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn. J Pediatr 1999; 134: 441-6.
  5. Burchell B, Soars M, Monaghan G et al. Drug-mediated toxicity caused by genetic deficiency of UDP- glucuronosyltransferases. Toxicol Lett 2000; 112-113: 333-40.
  6. Cassidy AJ, van Steensel MA, Steijlen PM et al. A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am J Hum Genet 2005; 77: 909-17.
  7. McLean WH, Smith FJ, Cassidy AJ. Insights into genotype-phenotype correlation in pachyonychia congenita from the human intermediate filament mutation database. J Investig Dermatol Symp Proc 2005; 10: 31-6.
  8. Smith FJ, Liao H, Cassidy AJ et al. The genetic basis of pachyonychia congenita. J Investig Dermatol Symp Proc 2005; 10: 21-30.
  9. Sandilands A, O'Regan GM, Liao H et al. Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis. The Journal of investigative dermatology 2006; 126: 1770-5.
  10. Godfrey V, Chan SL, Cassidy A et al. The Functional Consequence of the Glu298Asp Polymorphism of the Endothelial Nitric Oxide Synthase Gene in Young Healthy Volunteers. Cardiovascular drug reviews 2007; 25: 280-8.
  11. Szeverenyi I, Cassidy AJ, Chung CW et al. The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases. Hum Mutat 2007.
  12. F. E. Paulin, M. O'Neill, G. McGregor, A. Cassidy, A. Ashfield, C. W. Ali, A. J. Munro, L. Baker, C. A. Purdie, D. P. Lane and A. M. Thompson (2008). "MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism." BMC Cancer 8(1): 281.
  13. Treharne KJ, Cassidy D, Goddard C, Colledge WH, Cassidy A, Mehta A (2009) Epithelial IgG and its relationship to the loss of F508 in the common mutant form of the cystic fibrosis transmembrane conductance regulator. FEBS Lett.

    Mrs Stephanie Reilly

Stephanie graduated from Dundee University in 2004 with first class honours in Anatomical Sciences. Before joining the  Genetics Core Services Unit in October 2009 she worked as a Research Assistant for the Cell Structure Research group at Dundee University.  During this time she worked on various research projects which has given her experience in a variety of molecular biology techniques.
Stephanie's role within the Facility is that of Senior DNA Analysis Technician where she is responsible for the day-to-day operation of the laboratory.

Publications
    

  1. D'Alessandro M, Coats SE, Morley SM, Mackintosh L, Tessari G, Turco A, Gerdes AM, Pichert G, Whittaker S, Brandrup F, Broesby-Olsen S, Gomez-Lira M, Girolomoni G, Maize JC, Feldman RJ, Kato N, Koga Y, Ferguson-Smith MA, Goudie DR, Lane EB.
    J Invest Dermatol. 2007 Oct;127(10):2336-44. Multiple self-healing squamous epithelioma in different ethnic groups: more than a founder mutation disorder?
  2. Liovic M, D'Alessandro M, Tomic-Canic M, Bolshakov VN, Coats SE, Lane EB. Exp Cell Res. 2009 Oct 15;315(17):2995-3003. Severe keratin 5 and 14 mutations induce down-regulation of junction proteins in keratinocytes.